一群科學家要對「惡魔之巔」的火山活動進行研究，根據活動數據「惡魔之巔」近期將會爆發，小鎮正在研擬疏散計畫，但老班堅決不撤離。好不容易明蒂十多歲的女兒妮可說服老班，一家人開著車趕緊下山，此時火山爆發了！從火山噴射出來的不只是岩漿跟火球，還有當年吃人的居民，他們渴望肉體獲得重生！
故事发生于德州电锯大屠杀事件的十三年后，警方一直无法破案，甚至找的尸体，然而电锯带给德州的恐惧却从未停止。探长域士决心要为当年被屠杀的兄弟报仇，多年来追查电锯食人家族的下落。唱片骑师史琪芝在接听听众点唱时，无意中听到电话筒内传来惨叫和电锯的声音，她主动向域士提供线索并不断在电台播放那段声带，意图引起电锯食人家族的注意。不出所料，声带惹怒了电锯食人家族，一场血肉横飞，惨绝人寰的大决战即将展开
When, at the beginning of Deus Irae, Father Javier stares at a crucifix, his expressions and his hands suggest that the nerves are consuming him. A flashback reveals that this priest devotes his life to visiting families that claim to have seen things that do not belong to this world and cleansing their homes from the demons that try to possess them. But, upon returning to those houses, he notices that the evidence is always destroyed. This way, he discovers that a clan is after him, and must decide whether to hide from them or join them. In times when horror cinema tends to fall into the hands of directors that seek to build narratives that are introspective and close to reality, Pedro Cristiani goes back to old-school horror, where gore and the physical experience are above any other kind of feeling. A cinema that places the camera in front of the faces of the bloodiest demons and, instead of giving logic to them, chooses to face them whatever the cost.
A neuroscientist's obsession with a drug that expands the human mind inadvertently unleashes a deadly supernatural force on his team.
